Synthesis of polyazamacrocyclic compounds via modified Richman-Atkins cyclization of beta-trimethylsilylethanesulfonamides.

نویسندگان

  • R C Hoye
  • J E Richman
  • G A Dantas
  • M F Lightbourne
  • L S Shinneman
چکیده

The Richman-Atkins cyclization remains one of the most widely used methods for the preparation of macrocyclic polyamines. The use of beta-trimethylsilylethanesulfonamides (SES-sulfonamides) for the preparation of polyazamacrocyclic compounds is described. This expands existing Richman-Atkins sulfonamide macrocyclization methodology, and it successfully enables preparation of labile polyaza[n](1,4)naphthalenophanes and polyaza[n](9,10)anthracenophanes, not previously available in appreciable quantities.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 66 8  شماره 

صفحات  -

تاریخ انتشار 2001